Described is a family of cell surface serpentine transmembrane antigens.
Two of the proteins in this family are expressed in the prostate, as well
as in prostate cancer, and thus members of this family have been termed
"STEAP" (Six Transmembrane Epithelial Antigen of the Prostate). Four
particular human STEAPs are described and characterized herein. The human
STEAPs exhibit a high degree of structural conservation among them but
show no significant structural homology to any known human proteins. The
prototype member of the STEAP family is STEAP-1, which appears to be a
type IIIa membrane protein. STEAP-1 is a 339 amino acid protein. STEAP-1
protein expression is maintained at high levels across various stages of
prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain
other human cancers.