Computer based systems, methods, software and databases are presented in which correlations between web items and pangenetic (genetic and epigenetic) attributes of individuals are determined and stored to generate a pangenetic based item feedback matrix. The pangenetic item feedback matrix can be used in computer based systems for web search, online recommendation of web items, web item satisfaction prediction, and online user behavior prediction to provide personalized results based on a user's pangenetic makeup. Data masking can be used to maintain privacy of sensitive portions of the pangenetic data.