A method of classifying a test subject comprises collecting imaging data for a plurality of training subjects, control subjects and a test subject. An intensity volume of interest (VOI) and a morphological VOI are selected from said imaging data. Training intensity data and morphological data are calculated for the intensity and spatial VOI. A statistical model can then be created based on the training intensity data and training spatial data to provide a universe of subjects. Control intensity data and spatial data are also calculated for the intensity and spatial VOI. A classifier can then be built dividing the universe into at least two regions. The test subject data can then be applied to the classifier to provide a determination of whether the test subject falls within the first region or the second region. The condition can be a neurological disease state such as temporal lobe epilepsy or Alzheimer's dementia.