L-nucleosides are conformationally constrained by at least one additional ring formed by a bridge connecting at least two atoms within a sugar moiety of the nucleoside. While a single additional ring is formed by bridging C.sub.1 -C.sub.4 atoms, two additional rings are formed by bridging both C.sub.1 -C.sub.2, and C.sub.3 -C.sub.4 atoms, or C.sub.1 -C.sub.3 and C.sub.2 -C.sub.4 atoms by bridges having the general structure A--B--Z. The conformationally constrained nucleosides may be incorporated into oligonucleotides and dinucleotides, and it is contemplated that compositions including the conformationally constrained nucleosides may have superior viral inhibitory or antineoplastic properties.

des L-nucléosides sont conformationally contraints par au moins un anneau additionnel constitué par un pont reliant au moins deux atomes dans une partie de sucre du nucléoside. Tandis qu'un anneau additionnel simple est constitué en jetant un pont sur C.sub.1 - les atomes C.sub.4, deux anneaux additionnels sont constitués en jetant un pont sur C.sub.1 - C.sub.2, et C.sub.3 - les atomes C.sub.4, ou C.sub.1 - C.sub.3 et C.sub.2 - atomes C.sub.4 par des ponts ayant la structure générale A -- b -- z. Les nucléosides conformationally contraints peuvent être incorporés aux oligonucléotides et aux dinucléotides, et on le contemple que les compositions comprenant les nucléosides conformationally contraints peuvent avoir les propriétés inhibitrices ou antinéoplastiques virales supérieures.

 
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> Multimerized DBH enhancer domains

> Chimeric gene formed of the DNA sequences that encode the antigenic determinants of four proteins of L. infantum, useful of serologic diagnosis of canine leishmaniosis and protein obtained

~ 00062