This invention relates generally to the asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.

Esta invención se relaciona generalmente con la síntesis asimétrica de quinazolin-2-ones que sean útiles pues los inhibidores del transcriptase reverso del VIH. La síntesis se logra a través de la adición mediada ligand chiral del cyclopropylacetylide.

 
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