This application is directed to a compound of Formula I ##STR1## wherein a, X, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, Crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.

Deze toepassing wordt geleid aan een samenstelling van Formule I ## STR1 ## waarin a, X, R.sup.1, R.sup.2, R.sup.3 en R.sup.4 zoals hierin bepaald zijn, nuttig in de behandeling van ademhalings, allergisch, reumatoïde, lichaamsgewichtregelgeving, ontstekings en centrale zenuwstelselwanorde zoals astma, chronische obstructieve longziekte, volwassen ademhalingsziektensyndroom, schok, bindweefselvermeerdering, longhypergevoeligheid, allergisch Rhinitis, atopic dermatitis, psoriasis, gewichtscontrole, reumatoïde artritis, cachexie, Crohn's ziekte, ulcerative colitis, jichtige voorwaarden en andere ontstekingsziekten, depressie, multi-infarctzwakzinnigheid en AIDS.

 
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