A process is disclosed for the preparation of simvastatin and its analogs through a novel intermediate (III), which enables a selective .alpha. carbon alkylation of the C-8 acyl side chain.

Процесс показан для подготовки simvastatin и своих аналогов до промежуточное звено романа (iii), которое включает селективное alpha. алкилирование углерода цепи ацила C-8 бортовой.
 
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< Process for manufacturing simvastatin and the novel intermediates

< Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1' (S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)

> Process for producing simvastatin and/or its derivatives

> Process for producing simvastatin
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