The small nonpeptides of the instant invention are tachykinin antagonists.
The compounds are highly selective and functional NK.sub.3 antagonists
expected to be useful in the treatment of pain, depression, anxiety,
panic, schizophrenia, neuralgia, addiction disorders, inflammatory
diseases, gastrointestinal disorders, vascular disorders, and
neuropathological disorders.
Os nonpeptides pequenos da invenção instantânea são antagonistas do tachykinin. Os compostos são os antagonistas NK.sub.3 altamente seletivos e funcionais esperados ser úteis no tratamento da dor, do depression, da ansiedade, do pânico, da esquizofrenia, do neuralgia, dos disorders do addiction, de doenças inflammatory, de disorders gastrointestinal, de disorders vascular, e de disorders neuropathological.