The present invention relates to herpes simplex virus (HSV) amplicon vectors, and in particular, HSV-1 amplicon vectors, which have been genetically modified and used alone or with consequent genetically modified HSV virus, to target a selected cell type, such as neoplastic cells. The present invention also relates to methods of using such vectors to target a cell, in order to treat a pathologic condition, such as cancer.

A invenção atual relaciona-se aos vetores simples do amplicon do vírus do herpes (HSV), e no detalhe, os vetores do amplicon HSV-1, que genetically foram modificados e usados sozinho ou com o vírus genetically modificado do conseqüente HSV, para alvejar um tipo selecionado da pilha, tal como pilhas neoplastic. A invenção atual relaciona-se também aos métodos de usar tais vetores alvejar uma pilha, a fim tratar uma condição pathologic, tal como o cancer.

 
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