A syringe drench adapter for livestock includes a collar having a frustroconical nose and a generally cylindrical skirt extending from the nose which is removably fittable over an end of a syringe, and an elongated tube extending from the nose. The skirt defines a syringe-receiving opening having an inner diameter which is less than an outer diameter of the syringe barrel. The skirt includes a circumferential ridge which extends radially inwardly and is disposed adjacent to the syringe-receiving opening, and a plurality of longitudinal slots extending from the syringe-receiving opening which provide flexion. The slots are disposed about the periphery of the skirt and are configured so as to reveal syringe measurement markings when the collar is fitted over the end of the syringe. The elongated tube defines a fluid passageway having an inlet removably connected to the nose of the collar, and an outlet for the expulsion of fluids. The fluid passageway adjacent to the inlet is configured to form-fit a nozzle of the syringe.