Succinate compounds, compositions and methods of use and preparation

   
   

Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

Se divulgan los compuestos del ácido hidroxámico de la novela. Estos hydroxamates inhiben el deformylase peptidyl (pdf), una enzima presente en prokaryotes. Los hydroxymates son útiles como los antimicrobianos y antibióticos. Los compuestos de la invención exhiben la inhibición selectiva del deformylase peptidyl contra otros metalloproteinases tales como metalloproteinases de la matriz (MMPs). Los métodos de síntesis y de uso de los compuestos también se divulgan.

 
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