Delivery of therapeutic gene products by intestinal cell expression

   
   

The present invention provides methods of delivering a secreted protein into the bloodstream of a mammal. A nucleic acid molecule encoding the protein is introduced into the gastrointestinal tract of the mammal, and the nucleic acid molecule enters an intestinal epithelial cell, where the protein is produced and secreted into the bloodstream of the mammal.

La actual invención proporciona métodos de entregar una proteína secretada en la circulación sanguínea de un mamífero. Una molécula del ácido nucleic que codifica la proteína se introduce en el aparato gastrointestinal del mamífero, y la molécula del ácido nucleic incorpora una célula epitelial intestinal, donde la proteína se produce y se secreta en la circulación sanguínea del mamífero.

 
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