Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders

   
   

Disclosed are novel nucleic acid and peptide compositions comprising methythlioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and idenification tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.

Показаны составы нуклеиновой кислоты и пептида романа состоя из фосфорилазы methythlioadenosine (MTAP) и методы пользы для последовательностей amino acid MTAP и этапов ДНАА состоя из MTAP в диагнозе людских раков и развитие МТАП-speqificeski антител. Также показаны методы для диагноза и обработки туморов и других proliferative разладов клетки, и гены усмирителя тумора idenification и продукты гена от людской зоны хромосомы 9p21-p22. Такие методы полезны в диагнозе множественных типов тумора such as рак пузыря, рак легких, рака груди, поджелудочный рак, туморы мозга, лимфомы, gliomas, melanomas, и лейковы.

 
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