Genes for familial hemeplegic migraine (FHM), episodic ataxia type-2
(EA-2), common forms of migraine, and other episodic neurological
disorders, such as epilepsy, have been mapped to chromosome 19p13. A
brain-specific P/Q type calcium channel subunit gene, covering 300 kb
with 47 exons is provided. The exons and their surroundings reveal
polymorphic variations and deleterious mutations that are linked to
various types of cation channel dysfunctions causing episodic
neurological disorders in man or animals.
