A method of operating a sheet-fed printing press having a sheet guide module,
removable
from the sheet-fed printing press and then inserted back into the sheet-fed printing
press again, and a machine control system, includes the steps of monitoring a position
of the sheet guide module with respect to its correct operating position with the
machine control system, and, based upon results of the position monitoring, the
machine control system keeping the sheet-fed printing process in a first operating
mode when the sheet guide module is located in the correct operating position,
and keeping it in a second operating mode with at least one operating function
that is restricted as compared with the first operating mode when the sheet guide
module is out of the correct operating position. Also provided is a sheet-fed printing
press suitable for carrying out the method.