Provided are in vivo screening methods to detect and identify substances
that affect neuronal viability, and/or prevent neurodegeneration, and/or confer
neuroprotective effects. The screening methods utilize recombinant C. elegans
expressing a detectable marker in neuronal sub-groups and the use of neurotoxins
specific to specific neuronal cells. Also provided are methods for identifying
modulators of neurotransmitter transporters such as the dopamine transporter. Therefore,
the invention provides methods for identifying substances that can be used in the
prevention and therapy of neurodegenerative diseases.
