This invention relates to compounds, compositions, and methods useful for
modulating myostatin (GDF8) gene expression using short interfering
nucleic acid (siNA) molecules. This invention also relates to compounds,
compositions, and methods useful for modulating the expression and
activity of other genes involved in pathways of myostatin gene expression
and/or activity by RNA interference (RNAi) using small nucleic acid
molecules. In particular, the instant invention features small nucleic
acid molecules, such as short interfering nucleic acid (siNA), short
interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA),
and short hairpin RNA (shRNA) molecules and methods used to modulate the
expression of myostatin genes.
