The invention describes a new integrated separation and analysis system for analysis
and separation of at least one sample component, comprising a mass sensitive detector
(1) with ionization source (2), at least one mobile solid phase (3),
at least one sample component (4), one transport system (5) where
the mobile solid phase and the sample component are transported, and at least one
transport fluid (6). The sample component is separated at the interface
between the transport and the mass sensitive detector. Also, a method for analysis
and separation of sample components is included, utilizing the mentioned integrated
separation and analysis system. According to the method, the mobile solid phase
and the sample are separated before the mass analyzer, and the sample components
are transported towards the mass analyzer.