The present invention includes hyaluronic acid complexes of a monovalent
alkali metal salt of hyaluronic acid and a tetra alkyl ammonium halide
that are suitable for incorporation with tissue scaffolds that are
suitable for use in repair and/or regeneration of muscoloskeletal tissue
and that include a biodegradable, porous substrate made from a
biodegradable, hydrophobic polymer, where the hyaluronic acid complex is
substantially insoluble in water at room temperature, yet soluble in
mixtures of organic and aqueous solvents in which the selected
hydrophobic polymer is soluble.
