This invention relates to compounds, compositions, and methods useful for
modulating Myc and/or Myb gene expression using short interfering nucleic
acid (siNA) molecules. This invention also relates to compounds,
compositions, and methods useful for modulating the expression and
activity of other genes involved in pathways of Myc and/or Myb gene
expression and/or activity by RNA interference (RNAi) using small nucleic
acid molecules. In particular, the instant invention features small
nucleic acid molecules, such as short interfering nucleic acid (siNA),
short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA
(miRNA), and short hairpin RNA (shRNA) molecules and methods used to
modulate the expression of Myc and/or Myb (e.g., c-Myc, N-Myc, L-Myc,
c-Myb, a-Myb, b-Myb, and v-Myb) genes. The small nucleic acid molecules
are useful in the treatment of cancer and other diseases and disorders.
