This invention relates to compounds, compositions, and methods useful for
modulating 5-alpha reductase (SRD5A-1, SRD5A-2) and androgen receptor
(AR) gene expression using short interfering nucleic acid (siNA)
molecules. This invention also relates to compounds, compositions, and
methods useful for modulating the expression and activity of other genes
involved in pathways of 5-alpha reductase and androgen receptor (AR) gene
expression and/or activity by RNA interference (RNAi) using small nucleic
acid molecules. In particular, the instant invention features small
nucleic acid molecules, such as short interfering nucleic acid (siNA),
short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA
(mRNA), and short hairpin RNA (shRNA) molecules and methods used to
modulate the expression of 5-alpha reductase and androgen receptor (AR)
genes.
