Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors page

Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors

Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1##
wherein X, Z, X₁, R¹, R², R^a, R^b, R³, R⁴and Y are as defined in the specification.

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