The invention provides a solid support for adsorbing a biomolecule. The support
comprises a surface coating having a non-nucleotidic polymer tethered to a surface
reactive site. The polymer comprises a backbone, terminus, and adsorbing moieties
covalently attached to the backbone and capable of adsorbing a biomolecule that
can assume a plurality of conformations. The polymer is generally tethered to the
surface at its terminus and the backbone exhibits sufficient mobility and flexibility
such that a biomolecule adsorbed by the adsorbing moieties can assume a desired
conformation for hybridization. Also provided is a process for preparing a surface
coating having a functionalized surface.
