In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J.sup.1-J.sup.3, X, Z, and R.sup.1-R.sup.4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

 
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> Fused tricyclic mGIuR1 antagonists as therapeutic agents

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