The present invention relates to inhibitors of serotonin and/or norepinephrine reuptake and specifically provides compounds of formula (I): wherein A is selected from --O-- and --S--; X is selected from C.sub.1-C.sub.8 alkyl, C.sub.2-C.sub.8 alkenyl, and C.sub.4-C.sub.8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from phenyl, pyrrolidinyl, piperidinyl, morpholinyl, halo, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy, C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2, --CF.sub.3, --CN and --CONH.sub.2; Y is selected from (a), (b), (c), (d), (e), (f) where R.sub.3, R.sub.4 and R.sub.5 are independently selected from hydrogen, halo, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy, C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2, nitro, acetyl, --CF.sub.3, --SCF.sub.3 and cyano; R.sub.6 and R.sub.7 are independently selected from halo, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy, C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2, nitro, acetyl, --CF.sub.3, --SCF.sub.3 and cyano; R.sub.8 is selected from chloro, bromo, iodo, C.sub.1-C.sub.4alkyl, C.sub.1-C.sub.4 alkoxy, C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2, nitro, acetyl, --CF.sub.3, --SCF.sub.3 and cyano; R.sub.1 and R.sub.2 are each independently hydrogen or C.sub.1-C.sub.4 alkyl; or pharmaceutically acceptable salts thereof; or compositions thereof and methods of using the same.

 
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> Fused tricyclic mGluR1 antagonists as therapeutic agents

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