The present invention relates to inhibitors of serotonin and/or
norepinephrine reuptake and specifically provides compounds of formula
(I): wherein A is selected from --O-- and --S--; X is selected from
C.sub.1-C.sub.8 alkyl, C.sub.2-C.sub.8 alkenyl, and C.sub.4-C.sub.8
cycloalkylalkyl, each of which may be optionally substituted with up to 3
substituents each independently selected from phenyl, pyrrolidinyl,
piperidinyl, morpholinyl, halo, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4
alkoxy, C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2,
--CF.sub.3, --CN and --CONH.sub.2; Y is selected from (a), (b), (c), (d),
(e), (f) where R.sub.3, R.sub.4 and R.sub.5 are independently selected
from hydrogen, halo, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy,
C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2, nitro, acetyl,
--CF.sub.3, --SCF.sub.3 and cyano; R.sub.6 and R.sub.7 are independently
selected from halo, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy,
C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2, nitro, acetyl,
--CF.sub.3, --SCF.sub.3 and cyano; R.sub.8 is selected from chloro,
bromo, iodo, C.sub.1-C.sub.4alkyl, C.sub.1-C.sub.4 alkoxy,
C.sub.1-C.sub.4 alkyl-S(O).sub.n-- where n is 0, 1 or 2, nitro, acetyl,
--CF.sub.3, --SCF.sub.3 and cyano; R.sub.1 and R.sub.2 are each
independently hydrogen or C.sub.1-C.sub.4 alkyl; or pharmaceutically
acceptable salts thereof; or compositions thereof and methods of using
the same.