Amino alcohol compounds and phosphonic acid compounds having excellent immunosuppressive activity, pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof, and pharmaceutical compositions comprising such compounds, the compounds having the following formula: ##STR00001## wherein R.sup.1 and R.sup.2 each represent hydrogen, or a protecting group of the amino group; R.sup.3 represents hydrogen, or a protecting group of the hydroxyl group; R.sup.4 represents a lower alkyl group; n is 1 to 6; X represents oxygen or nitrogen, which is unsubstituted or substituted with a lower alkyl group; Y represents ethylene; Z represents a C.sub.1 C.sub.10 alkylene; R.sup.5 represents an aryl group; and R.sup.6 and R.sup.7 each represents hydrogen; provided that when R.sup.5 represents hydrogen, then Z represents a group other than a single bond or a straight chain C.sub.1 C.sub.10 alkylene group.

 
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