Disclosed herein are modified proaerolysin (PA) peptide. In some examples,
the proteins include a prostate-specific protease cleavage site and can
further include a prostate-tissue-specific binding domain which
functionally replaces the native PA binding domain. In other examples,
the proteins include a furin cleavage site and a prostate tissue-specific
binding domain which functionally replaces the native PA binding domain.
Methods of using such peptides to treat prostate cancer are also
disclosed.