A non-irritating multi-ply absorbent article made by treating an inner surface with one or more antimicrobial agents and treating the one or more outer surfaces with one or more siloxane compositions, and methods of making and using the same. The antimicrobial agent will remain confined to the inner portion of the absorbent article, thereby preventing irritation to the user, and the siloxane treated ply(s) will provide a pleasing, soothing, non-irritating tactile quality. In one embodiment, the siloxane composition comprises an amine-modified polysiloxane, in which case the product will also entrap any absorbed fluid, holding it in contact with the antimicrobial agent, and preventing it from wetting through the product and contacting the user.