A compression device includes a frame mountable to a mammography unit that includes a window disposed within an x-ray field of the mammography unit when the frame is mounted to the mammography unit, and a radiolucent compressible member connectable to the frame across the window for providing a compression surface within the x-ray field. For example, the compressible member may include a rigid backing member and a radiolucent pad, e.g., a gel pad, on the backing member. The backing member and frame may include tongue and groove or other connectors for connecting the compressible member to the frame. Optionally, one or more thin, radiolucent films may be removable from the compressible member, e.g., after obtaining x-rays from successive individual patients.